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Anti-Human CTNNA1 DyLight® 550 conjugated Antibody

Hersteller Boster
Kategorie
Typ Antibody Primary
Specific against Human
Isotype IgG
Format Liquid
Applikationen FC
Menge 100 ug/vial
Host Rabbit
ArtNr BOS-A01617-Dyl550
Konjugat/Tag DyLight 500
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Manufacturers Product Category
Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category
Actin, etc., Cadherins, Cancer, Cell Adhesion, Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Invasion/Microenvironment, Microfilaments, Signal Transduction, Signaling Pathways, Stem Cells
Short Description
Boster Bio Anti-Human CTNNA1 DyLight® 550 conjugated Antibody catalog # A01617-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Description
Boster Bio Anti-Human CTNNA1 DyLight® 550 conjugated Antibody catalog # A01617-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Background
CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.
Gene Name
CTNNA1
Application Details
Flow Cytometry, 1-3μg/1x106 cells
Clonality
Polyclonal
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Immunogen
E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.
Cross-reactivity
No cross-reactivity with other proteins.
Storage
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Gene Full Name
catenin (cadherin-associated protein), alpha 1, 102kDa
Protein Function
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Subcellular Localization
Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity
Expressed ubiquitously in normal tissues.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

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