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Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody

Hersteller Boster
Kategorie
Typ Antibody Primary
Specific against Human
Isotype IgG
Format Liquid
Applikationen FC
Menge 100 ug/vial
Host Rabbit
ArtNr BOS-A01651-Dyl488
Konjugat/Tag DyLight 488
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Manufacturers Product Category
Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category
Microbiology
Short Description
Boster Bio Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody catalog # A01651-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Description
Boster Bio Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody catalog # A01651-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Background
SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.
Gene Name
SCRIB
Application Details
Flow Cytometry, 1-3μg/1x106 cells
Clonality
Polyclonal
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Immunogen
E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409).
Cross-reactivity
No cross-reactivity with other proteins.
Storage
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Gene Full Name
scribbled planar cell polarity protein
Protein Function
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
Subcellular Localization
Cell membrane.
Tissue Specificity
Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

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