Vergleich

Anti-Human PRX DyLight® 550 conjugated Antibody

Hersteller Boster
Kategorie
Typ Antibody Primary
Specific against Human
Isotype IgG
Format Liquid
Applikationen FC
Menge 100 ug/vial
Host Rabbit
ArtNr BOS-A01686-Dyl550
Konjugat/Tag DyLight 500
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Manufacturers Product Category
Primary Antibodies, Rabbit Polyclonal Antibodies
Short Description
Boster Bio Anti-Human PRX DyLight® 550 conjugated Antibody catalog # A01686-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Description
Boster Bio Anti-Human PRX DyLight® 550 conjugated Antibody catalog # A01686-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Background
Periaxin is a protein that in humans is encoded by the PRX gene. This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.
Gene Name
PRX
Application Details
Flow Cytometry, 1-3μg/1x106 cells
Clonality
Polyclonal
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Immunogen
E. coli-derived human PRX recombinant protein (Position: M1-K91).
Cross-reactivity
No cross-reactivity with other proteins.
Storage
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Gene Full Name
periaxin
Protein Function
Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.
Subcellular Localization
Isoform 1: Cell membrane
Tissue Specificity
Detected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

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