Anti-eIF5A Antibody

Polyclonal

Polyclonal antibody for EIF5A detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. EIF5A information: Molecular Weight: 16832 MW; Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions; Tissue Specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).

A peptide derived from human eIF5A. Immunogen sequence location: 79 - 128

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. .

Human, Mouse, Rat

At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.