Anti-Human CCR3 DyLight® 488 conjugated Antibody

Primary Antibodies, Rabbit Polyclonal Antibodies

Boster Bio Anti-Human CCR3 DyLight® 488 conjugated Antibody catalog # A01748-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

C-C chemokine receptor type 3, also called CCR3 or CKR3 is a protein that in humans is encoded by the CCR3 gene. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. Alternatively spliced transcript variants have been described.

Flow Cytometry, 1-3μg/1x10⁶ cells

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

A synthetic peptide corresponding to a sequence at the N-terminus of human CCR3.

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

In eosinophils as well as trace amounts in neutrophils and monocytes.