Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody Primary |
Specific against |
Human |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
FC |
Menge |
100 ug/vial |
Host |
Rabbit |
ArtNr |
BOS-A01879-Dyl550 |
Konjugat/Tag |
DyLight 500 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Apoptosis, Associated Proteins, Cell Biology, Developmental Biology, Intracellular, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction |
Short Description |
Boster Bio Anti-Human PDCD10 DyLight® 550 conjugated Antibody catalog # A01879-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Human PDCD10 DyLight® 550 conjugated Antibody catalog # A01879-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Background |
Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Gene Name |
PDCD10 |
Application Details |
Flow Cytometry, 1-3μg/1x106 cells |
Clonality |
Polyclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
Immunogen |
E. coli-derived human PDCD10 recombinant protein (Position: M1-A212). |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
Gene Full Name |
programmed cell death 10 |
Protein Function |
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). |
Subcellular Localization |
Cytoplasm. Golgi apparatus membrane; Partially co- localizes with endogenous PXN at the leading edges of migrating cells. |
Tissue Specificity |
Ubiquitous. |
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