Anti-KCNN4 Antibody

Hersteller Boster
Kategorie
Typ Antibody Primary
Specific against other
Isotype IgG
Format Lyophilized
Applikationen WB, ELISA
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A01936-2
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Clonality
Polyclonal
Description short
Rabbit IgG polyclonal antibody for KCNN4 detection. Tested with WB, Direct ELISA in Human, Mouse, Rat.
Specificity
No cross reactivity with other proteins.
Reactivity
Reacts with: human, mouse, rat
Application details
Western blot|0.1-0.5μ g/ml
Direct ELISA|0.1-0.5μ g/ml
Notes
Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Immunogen
E. coli-derived human KCNN4 recombinant protein (Position: K309-Q364).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Relevant detection systems
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Background
Intermediate conductance calcium-activated potassium channel protein 1 (KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Reference
1. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. Joiner, W.J., Wang, L.Y., Tang, M.D. and Kaczmarek, L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. U.S.A.1997; 94 (20), 11013-11018.
2. Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U.S.A.2003; 100 (12), 7366-7371.
3. Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J. Biol. Chem.2004; 279 (15), 15531-15540.
Gene Name
KCNN4
Protein Name
Intermediate conductance calcium-activated potassium channel protein 4
Gene Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Synonyms
Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel; KCNN4; IK1; IKCA1; KCA4; SK4
Uniprot ID
O15554
Entrez GeneID
3783
Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 240,00 €
Preis: 240,00 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen