Anti-GPR120 Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB, IF, IHC
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A19859
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
FFAR4
Clonality
Polyclonal
Conjugate
No
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Description
Polyclonal antibody for GPR120/FFAR4 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IF. Reactive species: Human. GPR120/FFAR4 information: Molecular Weight: 42241 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Colocalized with ARRB2 following DHA treatment; Tissue Specificity: Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.
Uniprot ID
Q5NUL3
Immunogen
A peptide derived from human GPR120. Immunogen sequence location: 221 - 270
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
User need to optimize the dilution ratio for this antibody
Reactivity
Human, Mouse, Rat
Research category
FFAR4
Synonyms
Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1, FFAR4, GPR120, GPR129, O3FAR1, PGR4,
Molecular weight
42241 MW
Protein function
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. .
Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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