Antibodies

Anti-8ODP Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB
Menge 100ul
Host Rabbit
ArtNr BOS-A30008
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
NUDT1
Clonality
Polyclonal
Conjugate
No
Contents
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description
Polyclonal antibody for MTH1/NUDT1 detection. Host: Rabbit.Size: 100ul. Tested applications: WB. Reactive species: Human. MTH1/NUDT1 information: Molecular Weight: 22520 MW; Subcellular Localization: Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria; Tissue Specificity: Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Uniprot ID
P36639
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human 8ODP
Purification
Immunogen Affinity purified
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
WB: Dilution:1.0ug/ml
Reactivity
Human, Mouse, Rat
Predicted reactivity
Bovine, Canine, Equine, Guinea Pig, Rabbit, Zebrafish
Research category
8ODP
Synonyms
7, 8-dihydro-8-oxoguanine triphosphatase, 3.6.1.55, 2-hydroxy-dATP diphosphatase, 3.6.1.56, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, NUDT1, MTH1,
Molecular weight
22520 MW
Protein function
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. .

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Menge: 100ul
Lieferbar: Out of stock
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