Antibodies

Anti-ADSV Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB
Menge 100ul
Host Rabbit
ArtNr BOS-A30013
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
SCIN
Clonality
Polyclonal
Conjugate
No
Contents
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description
Polyclonal antibody for ADSEVERIN/SCIN detection. Host: Rabbit.Size: 100ul. Tested applications: WB. Reactive species: Human. ADSEVERIN/SCIN information: Molecular Weight: 80489 MW; Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, podosome ; Tissue Specificity: Expressed in megakaryocytes.
Uniprot ID
Q9Y6U3-2
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human ADSV
Purification
Immunogen Affinity purified
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
WB: Dilution:1.0ug/ml
Reactivity
Human
Research category
ADSV
Synonyms
Adseverin, Scinderin, SCIN, KIAA1905,
Molecular weight
80489 MW
Protein function
Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4, 5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). .
Menge: 100ul
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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