Anti-Human IRS1 DyLight® 488 conjugated Antibody(monoclonal, 10I3)

Primary Antibodies

39 kDa

Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human

insulin receptor substrate 1

Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.

Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Angiogenesis, Cardiovascular, Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Structures, TGF Beta

ciliary basal body; cytosol; nucleus; caveola; insulin receptor complex; plasma membrane; cytoplasm; intracellular membrane-bounded organelle; Complete GO annotation on QuickGO

Expressed in osteoblasts, but not in osteoclasts.