EFNA5 Ephrin A5 Human Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile Filtered colorless solution.
Menge 10ug
ArtNr BOS-PROTP52803
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
EFNA5
Conjugate
No
Contents
EFNA5 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Description
EFNA5 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 422 amino acids (21-203 a.a.) and having a molecular mass of 48.1kDa. (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).EFNA5 is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
Short description
EFNA5 produced in Sf9 Baculovirus cells is a single, glycosylatedpolypeptide chain containing 422 amino acids (21-203 a.a.) and having amolecular mass of 48.1kDa. (Migrates at 40-57kDa on SDS-PAGE under reducingconditions).EFNA5 is expressed with a 239 amino acid hIgG-His-tag atC-Terminus and purified by proprietary chromatographic techniques.
Uniprot ID
P52803
Purification
Greaterthan 95.0% as determined by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; EFNA5; EPLG7, LERK7;
Protein function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Subcellular localization
Cell membrane
Source
Sf9, Baculovirus cells.
Shipping
Shipped with wet ice

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Menge: 10ug
Lieferbar: In stock
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