AK2 Adenylate Kinase 2 Human Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile filtered colorless solution.
Menge 10ug
ArtNr BOS-PROTP54819
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
AK2
Conjugate
No
Contents
AK2 solution containing 20mM Tris pH-7.5, 5mM DTT and 20% glycerol.
Description
AK2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 259 amino acids and having a molecular mass of 28.6 kDa.
AK2 is fused to 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Short description
AK2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 259 amino acids and having a molecular mass of 28.6 kDa.
AK2 is fused to 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Uniprot ID
P54819
Purification
Greater than 95.0% as determined by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Adenylate kinase 2, mitochondrial
Protein function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Subcellular localization
Mitochondrion intermembrane space
Tissue specificity
Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
Source
E. Coli
Shipping
Shipped with wet ice

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Menge: 10ug
Lieferbar: In stock
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