IFN Interferon-Tau Ovine Recombinant Protein

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Hersteller Boster
Kategorie
Typ Proteins Recombinant
Specific against other
Format Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 10ug
ArtNr BOS-PROTP56828
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene name
IFNT1
Conjugate
No
Contents
Lyophilized from (1mg/ml) solution containing PBS pH-7.4.
Description
Interferon-Tau Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton.
The IFN-Tau is purified by proprietary chromatographic techniques.
Short description
Interferon-Tau Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton.
The IFN-Tau is purified by proprietary chromatographic techniques.
Uniprot ID
P56828
Purification
Greater than 95.0% as determined by both:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Storage
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Synonyms
Interferon tau-1; IFN-tau-1; Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1; Trophoblastin; IFNT1; OTP;
Protein function
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Subcellular localization
Secreted. Secreted into the uterine lumen.
Tissue specificity
Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.
Source
E. Coli
Shipping
Shipped with wet ice

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Menge: 10ug
Lieferbar: In stock
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