Antibodies

Mouse Anti-Human DFF45 Clone 6B8SG Affinity Purified mAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Clon 6B8SG
Isotype IgG1
Applikationen WB
Menge 100 ug
Host Mouse
ArtNr CS-CMD102
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Mouse Anti-Human DFF45 Clone 6B8SG Affinity Purified monoclonal antibody. During apoptosis, various stimuli activate a protease cascade of caspases that eventually cause degradation of chromosomal DNA. DFF45 (DNA fragmentation factor 45) is a downstream regulator of DNA degradation (DFF40). DFF40 is an apoptotic DNase with a high specific activity that exists in an inactive complex with DFF45 in living cells. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40 release where it then enters nucleus to function as a nuclease. DFF45 may inhibit the DNAse activity of DFF40 and its nuclear translocation. Activation of DFF40 causes DNA degradation, a hallmark of apoptosis.
Formulation
Liquid in PBS + 50% glycerol + 0.5% BSA + 0.02% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Recognizes 45 and 40 kDa proteins, corresponding to the apparent molecular weight of human DFF45/ICADL and DFF45/ICADS respectively.
Immunogen
Recombinant human DFF45
Purification
Biospecific affinity chromatography
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Concentration
0.5 mg/ml
Application Notes
For Western Blot, use a working dilution of 0.5-4 ug/ml.The optimal concentration should be determined by the user for each specific application.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 626,84 €
Preis: 626,84 €
lieferbar

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