Antibodies

Mouse Anti-Multispecies Heat Shock Protein 90kDa alpha Class A Member 1 Clone S88 mAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Clon S88
Isotype IgG1
Applikationen WB
Menge 100 ug
Host Mouse
ArtNr CS-CMH116
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Applications
Western Blot Immunoprecipitation Immunohistochemistry
Description
Hsp90 (also known as Hsp82, Hsp83, or Hsp89), a 90 kDa protein, is the most abundant protein in the cytosolic fraction in many cell types. The high level of Hsp90 in many cell types suggests that Hsp90 may play a general role in the cell, but little is known about its general function. Hsp90 has no known enzymatic activity, and thus it has been presumed that Hsp90 may function through protein-protein interactions. Hsp90 exists in a dimeric form and has been observed to bind to several cellular proteins such as retro-virus kinases (PP60v-src), steroid receptors, heme-regulated protein kinase, actin and tubulin. In this regard, Hsp90, like Hsp70, may function as a “molecular chaperone”. Hsp90 exists as two isoforms referred to as Hsp86 and HSP84 in mouse cells or Hsp90a and Hsp90a in human cells.
Formulation
Liquid in PBS + 1 mg/ml BSA + 50% glycerol + 0.2% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Recognizes a 90 kDa protein corresponding to the apparent molecular weight of Hsp90 on SDS-PAGE immunoblots. Detects both Hsp90 alpha and beta.
Immunogen
Achlya ambisexualis Hsp90
Purification
Affinity purified.
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Concentration
0.2 mg/ml
Cross-Reactivity
Reacts with human, mouse, rat, monkey, bovine, rabbit, guinea pig, dog, sheep, chicken, and pig.
Application Notes
Western blot analysis (1-2 ug/ml), immunoprecipitation (4-8 ug/ml) and Immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes a 90 kDa protein, corresponding to the apparent molecular weight of Hsp90 on SDS-PAGE immunoblots. This antibody detects both Hsp90 alpha and beta.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 1.068,01 €
Preis: 1.068,01 €
lieferbar

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