Mouse Anti-Human STAT1 Clone STAT1-79 mAb

STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT 1 and 2) involved in IFN-alphaƒnand IFN-gammaƒnsignal transduction. Since their initial identification, 5 more STAT proteins have been discovered (STAT 3, 4, 5a, 5b and 6). STATs undergo tyrosine phosphorylations in response to growth factor or cytokine signaling (in some cases mediated by JAK kinases [Janus Kinases 1, 2 and 3]), resulting in dimerization and translocation of STAT proteins to the nucleus. Phosphorylation at serine residues in certain STATs (STAT 1-alpha, 3, 4 and 5) has also been reported, and appears to be required for the maximal activation of these proteins. This antibody recognizes proteins of ca.91 and ca.84 kDa, identified as STAT 1-alphaƒnand beta. STAT 1 participates in a signaling pathway which is initiated by IFN-gamma. Purification: Purified from ascites by affinity chromatography. Immunogen: Recombinant human STAT1-alpha expressed in E. coli. Cross-reactivity: Human, mouse, and rat.