Mouse Anti-Human TLR2 Clone BV31-9 mAb

Mouse Anti-Human TLR2 Clone BV31-9 monoclonal antibody. The Toll-like receptor (TLR) family in mammalia comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Up-to-date, ten TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells. CD3+ T-cells and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL1, and IL10 up regulate TLR2, whereas IL4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Recombinant human TLR2

Store at -20C. For long term storage, aliquot and store at -80C. Avoid repeated freeze-thaw cycles.