Rabbit Anti-Human CALNA/PPP3CA Affinity Purified pAb

0.2 mg/ml

Rabbit Anti-Human Calcineurin A Affinity Purified polyclonal antibody. Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.

Synthetic peptide corresponding to residues surrounding amino acid 267 of human Calcineurin A

The antibody solution should be gently mixed before use.

Detects a 61 kDa band, corresponding to the expected molecular weight of Calcineurin A on immunoblots.