Rabbit Anti-Human CASP12 pAb

Hersteller Cell Sciences
Typ Antibody
Specific against Human
Applikationen WB
Menge 1.0 mg
ArtNr CS-CPC141C
eClass 6.1 32160702
eClass 9.0 32160702
Caspase-12 (small) antibody can be used for the detection of both the propeptide and cleaved forms of caspase-12 by Western blot at 0.5 to 2 ug/ml.
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including a-secretase presenilin and a-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-a. Caspase-12 is ubiquitously expressed in mouse tissues.
Antibody is supplied in PBS containing 0.02% sodium azide. Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.
Host info
Caspase-12 antibody (Small) was raised in rabbit. Please use anti-rabbit secondary antibodies.
Human Caspase-12 (Small) Peptide
Affinity chromatography purified via peptide column
Storage and Stability
Caspase-12 antibody (Small) can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Notes
Menge: 1.0 mg
Lieferbar: Out of stock
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