Rabbit Anti-Human FOXO3-alpha Affinity Purified pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPF110
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Rabbit Anti-Human Forkhead Box O3 Affinity Purified polyclonal antibody. Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes, including the cell cycle, apoptosis, DNA repair, stress resistance, and metabolism. FOXO proteins are negatively regulated by the phosphatidylinositol 3-kinase-Akt signaling pathway, which is activated by growth factors and cytokines. Recent studies indicate that the activities of FOXO proteins are also regulated by oxidative stress, which induces their phosphorylation, translocation to the nucleus, and acetylation- deacetylation. Similar to the tumor suppressor p53, FOXO is activated by stress and induces the expression of genes that contribute to cell-cycle arrest, suggesting that it also functions as a tumor suppressor.
Formulation
Liquid in PBS + 0.5% BSA + 30% glycerol + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Human FOXO3
Immunogen
Synthetic peptide corresponding to residues on the C-terminus of human FOXO3
Purification
Biospecific affinity chromatography
Storage and Stability
Store at 2-4C for short term storage or in working aliquots at -20C to -80C for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Reacts with human, mouse, and rat.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 659,19 €
Preis: 659,19 €
lieferbar

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