Rabbit Anti-Human PRKDC Affinity Purified pAb

0.5 mg/ml

Rabbit Anti-Human PRKDC Affinity Purified polyclonal antibody. DNA-dependent protein kinase (DNA-PK) is made up of 3 subunits, 2 Ku proteins and a large catalytic subunit (DNA-PKcs). DNA-PKcs falls into the phosphatidyl-inositol 3-kinase superfamily although it does have serine/threonine protein kinase activity. This subunit migrates on SDS-PAGE gels as an intact and smaller processed form. in vitro , DNA-PK phosphorylates several transcription factors and other DNA-binding proteins and is believed to play a role in DNA damage recognition, repair and transcription. There is evidence to suggest that DNA-PKcs may be a critical target for proteolysis by a caspase in apoptosis.

Synthetic peptide corresponding to residues surrounding amino acid 4088 of human DNA-PK.

Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.