Antibodies

Rabbit Anti-Mouse Casp12 Affinity Purified pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Mouse
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPC121
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Rabbit Anti-Mouse Caspase 12 Affinity Purified polyclonal antibody. Caspase 12 is involved in the endoplasmic reticulum (ER) stress pathway, the third signaling pathway that leads to programmed cell death (apoptosis). In this process, caspase 12 is located to the ER, but not to the cytoplasm or mitochondrion. It is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase 12 is localized to the ER with several proteins that are involved in Alzheimer’s disease including a-secretase presenilin and a-amyloid precursor protein (APP). Caspase 12 mediates cytotoxicity induced by amyloid-a. Caspase 12 is ubiquitously expressed in mouse tissues.
Formulation
Liquid in PBS, pH 7.2 + 30% glycerol + 0.5% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Detects Procaspase 12 (55 kDa) and cleavage Caspase 12 (36 kDa).
Immunogen
Synthetic peptide corresponding to residues surrounding amino acid 310 of mouse Caspase 12
Purification
Biospecific affinity chromatography
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Reacts with mouse and rat.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 913,97 €
Preis: 913,97 €
lieferbar

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