Native Bovine Aprotinin/BPTI

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Bovine
Menge 100 mg
Host Bovine
ArtNr CS-CRA207A
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. Aprotinin is present in blood and in most tissues, with a high concentration in lung. Aprotinin inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g. GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g. CD11b). Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids {C284H432N84O79S7} arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a MW = 6.512 kDa.
Formulation
The protein (1 mg/ml) is sterile filtered and lyophilized with no additives.
Reconstitution
Centrifuge vial prior to opening. First add sterile water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Lyophilized samples are stable at room temperature for 3 weeks, but it is recommended to store them desiccated at -20C to -80C. Upon reconstitution, protein may be stored at 2-4C for one week and for six months at -20C to -80C. Add a carrier protein (0.1% HSA or BSA) as a stabilizer for long term storage. Aliquot working solutions to, Avoid repeated freeze-thaw cycles.
GeneID
404172
Source
Bovine Lung
Purity
Greater than 98.0% as determined by analysis by RP-HPLC and SDS-PAGE.
Endotoxin Level
Less than 0.1 ng/ug (1 EU/ug) of the protein.
Biological Activity
6, 300 KIU (Kallikrein Inactivator Units) per mg, 4.85 TIU/mg. 1 Unit corresponds to 1 biological kallikrein inhibitor unit (KIU). 1 TIU =1, 300 KIU.

Arbeitsanleitung

CS-CRA207A.pdf

Menge: 100 mg
Lieferbar: In stock
Listenpreis: 361,94 €
Preis: 361,94 €
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