Native Human Coagulation Factor IX

Hersteller Cell Sciences
Kategorie Produkte / Proteins
Typ Proteins
Specific against Human
Menge 1000 IU
Host Human
ArtNr CS-CRA123C
Eclass 6.1 34160400
Eclass 9.0 42020190
Human Factor IX also called Christmas-Factor is a glycoprotein, which is synthesized in the liver and belongs to the serine proteases system and is part of the S1 peptidase family. Lack of Factor-IX causes Hemophilia-B meaning Christmas Disease. Factor-IX has a N-terminus region which contains 12xGla residues which assist the calcium dependent binding of Factor-IX to the phospholipid surface. Factor-IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage yields the intermediate IXa, which is subsequently converted to the fully active form IXab. Factor-IX binds initially to exosites on the factor XIa heavy chain, followed by interaction at the active site with subsequent bond cleavage. Coagulation factor IX is activated by interaction with the erythrocyte membrane, causing intrinsic coagulation. Chaperones & lectins act simultaneously to guarantee the proper folding of Factor-IX and the retention of mutant molecules. Human Factor IX, activated by either the Contact or Tissue Factor Pathway, is responsible for the activation of Factor X to Xa. Human Factor-IX produced from fresh frozen human plasma is a glycosylated polypeptide chain having a MW = 56 kDa
The Factor-IX was lyophilized from a sterile solution containing 20 mM Tris-HCl pH-7.4 + 0.1 M NaCl and 1 mM Benzamidine.
Centrifuge vial prior to opening. It is recommended to reconstitute the lyophilized 100 U Factor-IX in sterile 100 ul of 18 MU-cm water, which can then be further diluted to other aqueous solutions.
Storage and Stability
Lyophilized Factor-IX although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Factor-IX should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.
Human Plasma
Greater than 95.0% as determined by SDS-PAGE.
Endotoxin Level
Less than 0.1 ng/ug (1 EU/ug) of the protein.
Biological Activity
The activity per mg was tested and found to be 195 Units per mg.
Menge: 1000 IU
Lieferbar: Out of stock
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