Recombinant Human Apolipoprotein E4

Hersteller Cell Sciences
Kategorie Produkte / Proteins
Typ Proteins
Specific against Human
Menge 500 ug
Host E.coli
ArtNr CS-CRA404B
Eclass 6.1 34160400
Eclass 9.0 42020190
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms, E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.
Lyophilized from a sterile filtered solution without additives
Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration of 0.1-1.0 mg/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Store lyophilized protein below 0C. Reconstituted protein is stable for 1 week at 4C. For long term storage, aliquot and store at -20C. Avoid repeated freeze-thaw cycles.
E. coli
Molecular Weight
34.4 kDa
>90% as determined by SDS-PAGE and HPLC analyses
Endotoxin Level
<0.1 ng/ug of ApoE4
Menge: 500 ug
Lieferbar: In stock
Listenpreis: 488,97 €
Rabatt: -10,0%
Preis: 440,07 €
Sie sparen: 48,90 €

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