Recombinant Human Bone Morphogenetic Protein-4

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
Host E.coli
ArtNr CS-CRB105B
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Recombinant Human Bone Morphogenetic Protein-4 is a monomeric, non-glycosylated, polypeptide chain containing 116 amino acids. Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and one from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98% sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in 50 mM Na2CO3 + 5 mM DTT, pH 11.0
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
GeneID
652
Source
E. coli
Molecular Weight
13.0 kDa
Purity
>95.0% by HPLC and SDS-PAGE
Endotoxin Level
Less than 1 EU/ug as determined by LAL method.
AA Sequence
MSPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Menge: 10 ug
Lieferbar: In stock
Listenpreis: 318,01 €
Rabatt: -10,0%
Preis: 286,21 €
Sie sparen: 31,80 €
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Arbeitsanleitung

CS-CRB105B.pdf