Recombinant Human beta 2-Microglobulin

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 50 ug
Host E.coli
ArtNr CS-CRB116B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Beta 2 Microglobulin (B2M) is a protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with B2M is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. B2M associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of B2M. CD8 T cells cannot develop in the absence of MHC class I. B2M is present in small amounts in serum, CSF, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human B2M levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). B2M levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces. Recombinant Human B2M is a non-glycosylated polypeptide chain with a MW = 11.76 kDa. The protein is purified by proprietary chromatographic techniques.
Formulation
Lyophilized in PBS pH 7.4 + 0.05% NaN3.
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile distilled water to a concentration not less than 0.1 mg/mL.
Storage and Stability
Stable at 2-4C for 3 weeks, but best kept desiccated below -20C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
GeneID
567
Source
E. coli
Molecular Weight
11.76 kDa
Purity
>95.0% by RP-HPLC and SDS-PAGE.
Menge: 50 ug
Lieferbar: Out of stock
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