Recombinant Human BMP-14

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
Host E.coli
ArtNr CS-CRB125A
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
GDF5 is a bone morphogenetic protein (BMP). BMPs belong to the TGF-a superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, GDF5 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human GDF5 is a homodimeric protein consisting of two 120 amino acid polypeptide chains.
Formulation
Lyophilized from 10 mM sodium citrate, pH 3.5
Reconstitution
Centrifuge vial prior to opening. First add sterile distilled water containing BSA (50 ug BSA per 1 ug of protein) to the vial to fully solubilize the protein to a concentration of 0.1-1.0 mg/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed.
Storage and Stability
Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week at 2-4C. For long term storage, aliquot and store at -20C. Avoid repeated freeze-thaw cycles.
Source
E. coli
Molecular Weight
27 kDa
Purity
> 98% as determined by SDS-PAGE and HPLC analyses
Protein Accession No
NP_000548
Endotoxin Level
< 0.1 ng/ug of GDF5
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 is 1-2 ug/ml.
Menge: 10 ug
Lieferbar: In stock
Listenpreis: 349,81 €
Preis: 349,81 €
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