Recombinant Human 4-1BB Receptor

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
Host E.coli
ArtNr CS-CRB201C
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Human 4-1BB Receptor, also named TNFRSF9, is a single non-glycosylated polypeptide chain containing 166 amino acids. 4-1BB Receptor is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells.
Formulation
0.2 um sterile filtered and lyophilized in 10 mM PB, pH 8.0, + 150 mM NaCl.
Reconstitution
Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week at 2-4C. For long term storage, aliquot and store at -20C to -80C with a carrier protein (0.1% HSA or BSA) as a stabilizer. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.
GeneID
3604
Source
E. coli
Molecular Weight
17.7 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE and HPLC.
Endotoxin Level
< 1 EU/ug as determined by LAL method.
Biological Activity
Fully biologically active when compared to standard. The biological activity is measured by its binding ability in a functional ELISA. When Recombinant Human 4-1BB Receptor is immobilized at 10 ng/ml, the concentration of Recombinant Human 4-1BB Ligand that produces 50% optimal binding response is found to be approximately 0.5-2.5 ng/ml.
AA Sequence
ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGG QRTCDICRQC KGVFRTRKEC SSTSNAECDC TPGFHCLGAG CSMCEQDCKQ GQELTKKGCK DCCFGTFNDQ KRGICRPWTN CSLDGKSVLV NGTKERDVVC GPSPADLSPG ASSVTPPAPA REPGHS
Menge: 1.0 mg
Lieferbar: In stock
Listenpreis: 3.340,44 €
Preis: 3.340,44 €
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