Synthetic Human Bivalir*din

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 100 mg
ArtNr CS-CRB505C
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Bivalirudin directly inhibits thrombin by specifically binding as well to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Bivalirudin is a specific and reversible direct thrombin inhibitor. Thrombin, which is a serine protease, plays a central role in the thrombotic process, it cleaves fibrinogen into fibrin monomers and activates Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked structure which stabilizes the thrombus. Thrombin also activates Factors V and VIII, which promotes further thrombin generation, activates platelets, stimulating aggregation and granule release. Human Bivalirudin is a synthetic 20 amino acid peptide.
Formulation
Lyophilized with 0.5 mg Manntiol + 50 ug sodium hydroxide, pH 5.5.
Reconstitution
Centrifuge vial prior to opening. First add sterile water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Lyophilized samples are stable at room temperature for 3 weeks, but it is recommended to store them desiccated at -20C to -80C. Upon reconstitution, protein may be stored at 2-4C for one week and for six months at -20C to -80C. Add a carrier protein (0.1% HSA or BSA) as a stabilizer for long term storage. Avoid repeated freeze-thaw cycles.
Concentration
1 mg/ml
Molecular Weight
2.18 kDa
Purity
>98.0% as determined by analysis by RP-HPLC and SDS-PAGE.
Endotoxin Level
Less than 0.1 ng/ug (1 EU/ug) of the protein.
AA Sequence
Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asp-Gly-Asp-Phe-Glu-Glu-Ile- Pro-Glu-Glu-Tyr-Leu.
Menge: 100 mg
Lieferbar: In stock
Listenpreis: 907,91 €
Preis: 907,91 €
lieferbar

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