Native Human CAPN1

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
Host Human
ArtNr CS-CRC118C
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
CAPN1 consists of an 80 kDa large subunit and a 30 kDa small subunit. CAPN1 was purified by sequential chromatography through DEAE-Sepharose, A1.5 m Bio-Gel, and Phenyl-Sepharose CL-4B columns. Calpain’s activity is attributed to two main isoforms: u-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (u-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Formulation
50 mM imidazole-HCl + 100mM NaCl + 5mM EGTA + 1mM DTT and 10% sucrose.
Storage and Stability
CAPN1 although stable at 10C for 1 week, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
GeneID
823
Source
Human Erythrocytes.
Purity
Greater than 90% as determined by SDS-PAGE.
Menge: 10 ug
Lieferbar: Out of stock
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