Recombinant Human L-Selectin/CD62L His

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
Host E.coli
ArtNr CS-CRC145B
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Recombinant Human L-Selectin/CD62L His is a 294 amino acid protein comprising aa 39-332 fused to an N-Terminal His Tag. L-Selectin/CD62L belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4binding proteins. L-Selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. It may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17. L-Selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules (HEV). Ligands present on endothelial cells attach to leukocytes expressing L-selectin, which causes the leukocytes to become localized at the HEV. The receptor is also located on the cell surfaces of "naive" T cells, which have not yet encountered their particular antigen. This surface expression is lost following cell activation.
Formulation
Sterile filtered colorless solution in PBS + 50% Glycerol
Storage and Stability
Stable for 2 weeks at 2-4C. For long term use, aliquot and freeze -20C. Avoid repeated freeze-thaw cycles.
GeneID
6402
Source
E. coli
Molecular Weight
37.55 kDa
Purity
>95% by SDS-PAGE
Endotoxin Level
< 0.1 ng/ug of protein.
Menge: 10 ug
Lieferbar: In stock
Listenpreis: 318,01 €
Rabatt: -10,0%
Preis: 286,21 €
Sie sparen: 31,80 €
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Arbeitsanleitung

CS-CRC145B.pdf