Recombinant Human CEA

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 2 ug
Host Insect
ArtNr CS-CRC184A
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Carcinoembryonic antigen (CEA) is a glycoprotein present in fetal digestive-tract tissues, it’s involved in cell adhesion. The production of CEA stops before birth. CEA is called tumor marker since its elevated levels are found in the serum from individuals with colorectal, gastric, pancreatic, lung and breast carcinomas and in heavy smokers. There are also benign conditions that elevate CEA levels such as smoking, infection, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, and some benign tumors (in the equivalent organs which have cancers with elevated CEA). Typically, higher levels of CEA are found in men, smokers, and older individuals. The presence of CEA assists in screening, in evaluating recurrent or disseminated disease, and in determining the success of surgical removal of malignant tumors. CEA levels can be used as indicators of treatment success. The normal values range from 0.0 to 2.5 ng/ml of serum (from blood), in non-smokers, a greater amount than that may be suggestive of cancer. Levels above 20 ng/ml before treatment are associated with cancer which has already metastasized. Benign conditions do not usually cause a CEA increase over 10 ng/ml. The high levels of CEA should return to normal after successful therapy, however if during follow up there’s an elevation in CEA levels it indicates a recurrence of tumor. Carcinoembryonic antigen family belongs to the immunoglobulin superfamily, it consists of 29 genes, 18 of which are normally expressed. CEA Human Recombinant is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. CEA is a well-known tumor marker corresponding to the full length human CEA which is approximately 120, 000 Dalton.
Formulation
Sterile filtered liquid in 10 mM NaH2PO4, pH 7 + 150 mM NaCl
Storage and Stability
Store in working aliquots at -20C to -80C. Add a carrier protein (0.1% HSA or BSA) as a stabilizer for long term storage. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.
GeneID
1048
Source
Insect cells
Molecular Weight
120 kDa
Purity
> 90% as determined by RP-HPLC and SDS-PAGE analyses
Protein Accession No
NP_004354
Endotoxin Level
< 0.1 ng/ug of CEACAM5
Menge: 2 ug
Lieferbar: In stock
Listenpreis: 206,00 €
Rabatt: -10,0%
Preis: 185,40 €
Sie sparen: 20,60 €
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Arbeitsanleitung

CS-CRC184A.pdf