Recombinant Human D4*di

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 2 ug
Host E.coli
ArtNr CS-CRD112A
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Recombinant Human D4 GDI/RhoGDI-2 is comprised of the full length protein and is purified by proprietary chromatographic techniques. D4-GDI belongs to the family of Rho-GDIs or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins, consisting of RhoGDI-1, D4 GDI/RhoGDI-2 and RhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. D4-GDI is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis. D4-GDI is expressed only in hematopoietic tissues, mainly in B and T cells, unlike RhoGDI which is expressed ubiquitously. D4-GDI plays a role in the regulation of lymphocyte activation, survival, and responsiveness. Expression of D4-GDI is also observed in cells of nonhematopoietic neoplasms, including ovarian and bladder cancer cells, suggestive of D4-GDI’s role in progression of human tumors.
Formulation
Sterile filtered solution in 50 mM Tris-HCI, pH 7.5, + 10 mM L-Glutathione (reduced).
Storage and Stability
Store product at -80C. Stable for 1 year. For multiple use, aliquot and freeze at -80C. Avoid repeated freeze-thaw cycles.
GeneID
397
Source
E. coli
Molecular Weight
54 kDa
Purity
>90.0% by SDS-PAGE

Arbeitsanleitung

CS-CRD112A.pdf

Menge: 2 ug
Lieferbar: In stock
Listenpreis: 459,01 €
Preis: 459,01 €
lieferbar

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Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de