Recombinant Human EFNB1 His

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 5 ug
Host E.coli
ArtNr CS-CRE112A
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Recombinant Human Ephrin-B1 is comprised of aa 136-247 of the full length protein and is purified by proprietary chromatographic techniques. Ephrin-B1 is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. Based upon their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are attached to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Class A ephrins are linked to the membrane by a GPI linkage and bind primarily to EphA receptors, Class B ephrins contain a membrane-spanning region and bind primarily to EphB receptors. Ephrin-B1 binds to the receptor tyrosine kinases ephb1 and epha1. Both ephrins and Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. Ephrin-B1 may play a role in cell adhesion and function in the development or maintenance of the nervous system. It binds to and induces the collapse of commissural axons/growth cones, in vitro . Ephrin-B1 may play a role in constraining the orientation of longitudinally projecting axons (by similarity). Defects in the efnb1 gene are a cause of craniofrontonasal syndrome (CFNS), also known as craniofrontonasal dysplasia (CFND).
Formulation
Sterile filtered clear solution of 20 mM Tris-HCl buffer (pH 8.0) + 0.4 M Urea and 5% glycerol.
Storage and Stability
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
GeneID
1947
Source
E. coli
Molecular Weight
47 kDa by SDS-PAGE
Purity
Greater than 95% as determined by SDS-PAGE.
AA Sequence
MGSSHHHHHH SSGLVPRGSH MLAKNLEPVS WSSLNPKFLS GKGLVIYPKI GDKLDIICPR AEAGRPYEYY KLYLVRPEQA AACSTVLDPN VLVTCNRPEQ EIRFTIKFQE FSPNYMGLEF KKHHDYYITS TSNGSLEGLE NREGGVCRTR TMKIIMKVGQ DPNAVTPEQL TTSRPSKEAD NTVKMATQAP GSRGSLGDSD GKHETVNQEE KSGPGASGGS SGDPDGFFNS K
Menge: 5 ug
Lieferbar: In stock
Listenpreis: 226,60 €
Preis: 226,60 €
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