Native Human Fetuin alpha-2

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
ArtNr CS-CRF121A
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains. Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). Fetuin-A (alpha2-Heremans-Schmid glycoprotein, AHSG) is an important circulating inhibitor of calcification, in vivo , and is downregulated during the acute-phase response. Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation. Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
Formulation
Filtered (0.4 um) and lyophilized from 0.5 mg/ml in PBS pH 7.4.
Storage and Stability
Store the lyophilized protein at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time, it does not show any change after two weeks at 4C. The lyophilized protein remains stable until the expiration date when stored at -20C. Avoid repeated freeze-thaw cycles.
GeneID
197
Source
Purified from the human plasma.
Purity
Greater than 95% as determined by SDS-PAGE.
Menge: 10 ug
Lieferbar: Out of stock
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