Recombinant Human FLT3 (aa 571-993) GST Active

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 5 ug
Host Insect
ArtNr CS-CRF149A
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30% to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity.
Formulation
Recombinant protein stored in 50 mM Tris-HCl, pH 7.5 +, 150 mM NaCl + 0.25 mM DTT + 0.1 mM EGTA + 0.1 mM EDTA + 0.1 mM PMSF + 25% glycerol.
Storage and Stability
Store product at -80C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
GeneID
2322
Source
Sf9 insect cells using an N-terminal GST tag.
Molecular Weight
ca.73 kDa
Purity
The purity of FLT3 was determined to be >90% by densitometry,
Protein Accession No
NM_004119
Menge: 5 ug
Lieferbar: In stock
Listenpreis: 489,34 €
Preis: 489,34 €
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