Recombinant Human Galectin 3

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
Host E.coli
ArtNr CS-CRG003A
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galactin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant Galectin-3 is a globular 26.0kDa protein containing 250 amino acid residues, but no disulfide bonds.
Source
E. coli
Purity
Greater than 97% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per ug (1EU/ug).
Biological Activity
Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.
Format
Lyophilized

Arbeitsanleitung

CS-CRG003A.pdf

Menge: 10 ug
Lieferbar: In stock
Listenpreis: 349,81 €
Preis: 349,81 €
lieferbar

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