Recombinant Hir*din

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
ArtNr CS-CRH117C
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
Hirudin is the most potent natural thrombin-specific protease inhibitor, and is originally derived in the salivary glands of the medicinal leech. Unlike heparin, hirudin act directly on thrombin, rather than through other clotting factors. They have a high binding affinity and specificity for thrombin. Therefore, hirudin prevents or dissolves the formation of clots and thrombi, and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream.
Formulation
Lyophilized from a sterile filtered solution in 20 mM PBS, pH 7.0 + 2% mannitol
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
Source
Pichia Pastoris
Molecular Weight
ca.6.7 kDa
Purity
>96% by SDS-PAGE and HPLC analyses.
Specific Activity
The specific activity is no less than 10, 000 ATU/mg protein.
Endotoxin Level
Less than 1 EU/ug of rHirudin as determined by LAL method.
Biological Activity
The biological activity is determined by chromogenic assay, 1 unit is defined as the amount of Hirudin that neutralizes 1 unit of the WHO preparation 89/588 of thrombin.
AA Sequence
VVYTDCTESG QNLCLCEGSN VCGQGNKCIL GSDGEKNQCV TGEGTPGPQS HNDGDFEEPE EYL
Menge: 1.0 mg
Lieferbar: In stock
Listenpreis: 3.947,06 €
Preis: 3.947,06 €
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