Native B. nivea Cyclosporine-A

Hersteller Cell Sciences
Kategorie Produkte / Proteins
Typ Proteins
Specific against other
Menge 100 g
ArtNr CS-CRC171C
Eclass 6.1 34160400
Eclass 9.0 42020190
Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism. Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nivea. Chemically, cyclosporine is designated as [R-[R*, R*-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha-amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl). Molecular Formula: C62H111N11O12.
Lyophilized from a sterile filtered solution without additives
Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week at 2-4C. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freeze-thaw cycles.
Beauveria nivea
Molecular Weight
1, 202.64 Da
>98% as determined by RP-HPLC and Mass Spectral analyses (MALDI-TOF exhibits correct MW).
Menge: 100 g
Lieferbar: In stock
Listenpreis: 1.878,68 €
Rabatt: -10,0%
Preis: 1.690,81 €
Sie sparen: 187,87 €

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