ATR (Ab-428) Antibody

Polyclonal Antibody

ATR

Ataxia telangiectasia and Rad3 related antibody, Ataxia telangiectasia and Rad3-related protein antibody, ATR antibody, ATR_HUMAN antibody, FCTCS antibody, FRAP Related Protein 1 antibody, FRAP-related protein 1 antibody, FRP1 antibody, MEC1 antibody, MEC1 mitosis entry checkpoint 1 homolog antibody, Protein kinase ATR antibody, RAC3 antibody, Rad3 related protein antibody, SCKL antibody, SCKL1 antibody, Serine/threonine protein kinase ATR antibody, Serine/threonine-protein kinase ATR antibody

Peptide sequence around aa.426ca.430 (G-I-S-P-K) derived from Human ATR.

ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Zhou, X.Z. et al. (1999) Cell Mol. Life Sci. 56, 788-806.
Pinna, L.A. and Ruzzene, M. (1996) Biochim. Biophys. Acta 1314, 191-225.
Kastan, M.B. and Lim, D.S. (2000) Nat. Rev. Mol. Cell Biol. 1, 179-186.
Shechter, D. et al. (2004) DNA Repair (Amst) 3, 901-908.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Epigenetics and Nuclear Signaling

Peptide sequence around aa.426~430 (G-I-S-P-K) derived from Human ATR.