FLT3 (Ab-591) Antibody

Polyclonal Antibody

FLT3

CD 135 antibody, CD135 antibody, CD135 antigen antibody, Fetal liver kinase 2 antibody, FL cytokine receptor antibody, Flk 2 antibody, Flk2 antibody, Flt 3 antibody, FLT-3 antibody, Flt3 antibody, FLT3_HUMAN antibody, FMS like tyrosine kinase 3 antibody, Fms related tyrosine kinase 3 antibody, Fms-like tyrosine kinase 3 antibody, Growth factor receptor tyrosine kinase type III antibody, Ly-72 antibody, OTTHUMP0000004234 antibody, Receptor type tyrosine protein kinase FLT3 antibody, Stem cell tyrosine kinase 1 antibody, Stk 1 antibody, STK-1 antibody, Stk1 antibody, Tyrosine protein kinase receptor FLT3 antibody, Tyrosine-protein kinase receptor FLT3 antibody

Peptide sequence around aa.589ca.593 (Y-F-Y-V-D) derived from Human FLT3.

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Sekine S et, al. (2008) J Immunol. , 180(12):8126-34
Pratz K et, al. (2008) Leuk Lymphoma. 2008 , 49(5):852-63.
Al Shaer L et, al. (2008) Br J Haematol. 141(4):483-93.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunology

Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.