BRCA1 Antibody

Polyclonal Antibody

BRCA1

BRCA 1 antibody, BRCA1 antibody, BRCA1 DNA repair associated antibody, BRCA1/BRCA2 containing complex subunit 1 antibody, BRCA1/BRCA2-containing complex, subunit 1 antibody, BRCA1_HUMAN antibody, BRCAI antibody, BRCC 1 antibody, BRCC1 antibody, Breast and ovarian cancer susceptibility protein 1 antibody, Breast Cancer 1 antibody, Breast Cancer 1 Early Onset antibody, Breast cancer type 1 susceptibility protein antibody, BROVCA1 antibody, FANCS antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, Protein phosphatase 1 regulatory subunit 53 antibody, PSCP antibody, RING finger protein 53 antibody, RNF53 antibody

Fusion protein of human BRCA1

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Antigen Affinity Purified

Epigenetics and Nuclear Signaling

Fusion protein of Human BRCA1