Phospho-ATF1 (Ser63) Antibody

Polyclonal Antibody

ATF1

Activating transcription factor 1 antibody, ATF 1 antibody, atf1 antibody, ATF1 EWS fusion gene antibody, ATF1 FUS fusion gene antibody, ATF1_HUMAN antibody, cAMP dependent transcription factor 1 antibody, cAMP-dependent transcription factor ATF-1 antibody, Cyclic AMP dependent transcription factor ATF 1 antibody, Cyclic AMP dependent transcription factor ATF1 antibody, Cyclic AMP-dependent transcription factor ATF-1 antibody, EWS AFT1 antibody, FUS ATF 1 antibody, FUS/ATF 1 antibody, Protein TREB36 antibody, RNA binding protein activating transcription factor 1 fusion protein antibody, TREB 36 antibody, TREB36 antibody, TREB36 protein antibody

Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Mackenzie KF, et al. (2013) J Immunol 190, 565-77
Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26
Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Epigenetics and Nuclear Signaling

Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .