PDGFB Antibody

Polyclonal Antibody

PDGFB

Becaplermin antibody, c sis antibody, FLJ12858 antibody, Oncogene SIS antibody, PDGF 2 antibody, PDGF B chain antibody, PDGF Beta antibody, PDGF subunit B antibody, PDGF-2 antibody, PDGF2 antibody, Pdgfb antibody, PDGFB_HUMAN antibody, Platelet derived growth factor 2 antibody, Platelet derived growth factor B chain antibody, Platelet derived growth factor beta antibody, Platelet derived growth factor beta polypeptide (oncogene SIS) antibody, Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog) antibody, Platelet derived growth factor beta polypeptide antibody, Platelet-derived growth factor B chain antibody, Platelet-derived growth factor beta polypeptide antibody, Platelet-derived growth factor subunit B antibody, Proto-oncogene c-Sis antibody, Simian sarcoma viral (v sis) oncogene homolog antibody, SIS antibody, SSV antibody, v sis platelet derived growth factor beta polypeptide antibody

Recombinant protein of human PDGFB

PDGF-BB is a cystine-linked homodimer PDGF family member with key roles in development, cell proliferation, cell survival, and angiogenesis. PDGF-BB is expressed by vascular endothelium, megakaryocytes and Leydig cells. PDGF-BB targets pericytes, fibroblasts, monocytes and other cell types. PDGF induces fibroblast growth and migration and is a chemoattractant for monocytes and granulocytes. Precursor PDGF-BB is cleaved intracellularly to generate a form that contains a carboxy-terminal stretch that serves to retain PDGF-BB in the extracellular matrix. In a second cleavage event, the carboxy-terminal stretch is removed extracellularly to generate mature PDGF-BB. PDGF-BB binds to PDGFRbeta and induces receptor dimerization. Signaling is through the PI3K/Akt, JNK, and PLCgamma pathways. PDGF-BB may have a role in some cancer types.

Affinity-chromatography purified

Cardiovascular

Recombinant protein of Human PDGFB