HGS Antibody

Polyclonal Antibody

HGS

Hepatocyte growth factor regulated tyrosine kinase substrate antibody, Hepatocyte growth factor-regulated tyrosine kinase substrate antibody, HGF-regulated tyrosine kinase substrate antibody, HGNC:4897 antibody, HGS antibody, HGS_HUMAN antibody, Hrs antibody, Human growth factor regulated tyrosine kinase substrate antibody, Protein pp110 antibody, ZFYVE8 antibody

Synthesized peptide derived from internal of human HGS.

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Asao H., J. Biol. Chem. 272:32785-32791(1997).
Lu L., Gene 213:125-132(1998).
Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human HGS.