Phospho-PDGFRA (Tyr849) Antibody

Polyclonal Antibody

PDGFRA

Alpha-type platelet-derived growth factor receptor antibody, CD140 antigen-like family member A antibody, CD140a antibody, CD140a antigen antibody, MGC74795 antibody, PDGF alpha chain antibody, PDGF Receptor alpha antibody, PDGF-R-alpha antibody, PDGFR 2 antibody, PDGFR alpha antibody, PDGFR2 antibody, PDGFRA antibody, PDGFRA/BCR fusion antibody, PGFRA_HUMAN antibody, Platelet derived growth factor receptor 2 antibody, Platelet derived growth factor receptor alpha antibody, Platelet derived growth factor receptor alpha polypeptide antibody, Platelet derived growth factor receptor antibody, Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody, RHEPDGFRA antibody

Peptide sequence around phosphorylation site of Tyrosine849(S-N-Y(p)-V-S) derived from Human PDGFRa.

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.

Rikova K, et al. (2007) Cell 131, 1190-203
Moritz A, et al. (2010) Sci Signal 3, ra64
Guo A, et al. (2008) Proc Natl Acad Sci U S A 105, 692-7

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Cardiovascular

Peptide sequence around phosphorylation site of Tyrosine849(S-N-Y(p)-V-S) derived from Human PDGFRa.