Phospho-MAPK3 (Tyr205/222) Antibody

Polyclonal Antibody

MAPK1/MAPK3

ERK 2 antibody, ERK-2 antibody, ERT1 antibody, Extracellular Signal Regulated Kinase 2 antibody, Extracellular signal-regulated kinase 2 antibody, MAP kinase 1 antibody, MAP kinase 2 antibody, MAP kinase isoform p42 antibody, MAPK 1 antibody, MAPK 2 antibody, Mapk1 antibody, MAPK2 antibody, Mitogen-activated protein kinase 1 antibody, Mitogen-activated protein kinase 2 antibody, MK01_HUMAN antibody, P38 antibody, P40 antibody, P41 antibody, p42-MAPK antibody, P42MAPK antibody, PRKM1 antibody, PRKM2 antibody, protein kinase, mitogen-activated, 1 antibody, protein kinase, mitogen-activated, 2 antibody, protein tyrosine kinase ERK2 antibody

Peptide sequence around phosphorylation site of tyrosine 205/222(K-G-Y(p)-T-K) derived from Human MAPK1/3 .

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Owaki H., Biochem. Biophys. Res. Commun. 182:1416-1422(1992).
Dunham I., Nature 402:489-495(1999).

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Neuroscience

Peptide sequence around phosphorylation site of tyrosine 205/222(K-G-Y(p)-T-K) derived from Human MAPK1/3 .