Phospho-MAP2K1 (Thr291) Antibody

Polyclonal Antibody

MAP2K1

Dual specificity mitogen activated protein kinase kinase 1 antibody, Dual specificity mitogen-activated protein kinase kinase 1 antibody, ERK activator kinase 1 antibody, MAP kinase kinase 1 antibody, MAP kinase/Erk kinase 1 antibody, MAP2K1 antibody, MAPK/ERK kinase 1 antibody, MAPKK 1 antibody, MAPKK1 antibody, MEK 1 antibody, Mek1 antibody, MEKK1 antibody, Mitogen activated protein kinase kinase 1 antibody, MKK 1 antibody, MKK1 antibody, MP2K1_HUMAN antibody, PRKMK1 antibody, Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1) antibody, Protein kinase mitogen activated, kinase 1 antibody, protein kinase mitogen-activated kinase 1 antibody

Peptide sequence around phosphorylation site of threonine 291 (P-R-T(p)-P-G derived from Human MEK1.

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Kevin D. Burroughs, et, al. (2003) Mol. Cancer Res , 1: 312.
Michael J. Piatelli, et, al. (2002) J. Biol. Chem , 277: 12144 - 12150.
Margaret M. Morgan, et, al. (2001) J. Immunol , 167: 5708.
Herbert Schramek, et, al. (2003) Am J Physiol Cell Physiol, , 285: C652 - C661.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Signal Transduction

Peptide sequence around phosphorylation site of threonine 291 (P-R-T(p)-P-G derived from Human MEK1.